U.S. Patents


Plants, Plant Chemistry, Herbal Formulas


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CAUTION, PLEASE READ:  These patent abstracts are provided as a service to anyone who is interested in contacting the owners of the patents for investment purposes, possible product distribution and/or co-licensing.  Also, to those who may be seeking innovative therapies and would like to contact the inventor or licensee to check for research, FDA approval (where appropriate) and the availability of the product, process or formula.  An approved patent does not guarantee its reported use is defensible or novel.   It may or may not meet the litmus test of the FDA for drug approval. These patents in no way guarantee that the plants, extracts and processes covered do what they suggest they do.  Patents of plant drugs, herb formulas and plant chemistry may or may not be confirmed human  clinical trials testing for safety and efficacy.  There may or may not be a scientific justification for the claims made.

Patents do provide legal protection for the novel ideas of inventors.  

*NOTE: These abstracts do not contain all vital information.  HerbalGram, the publication of the American Botanical Society, covers new patents in each issue. For more information see the ABC web site at www.herbalgram.org.

ON LINE PATENT SEARCHES:  U.S. Patents and patent applications may be searched in a number of ways at www.uspto.gov.   Try using a boolean two word search.  For example:  Enter Ginkgo in window one and biloba in window two, then press search button.  This will give you a list of U.S. Patents (from most recent to older) where Ginkgo biloba is a component.  Or for a broader search you might type in gall in one window and stones in the other to search recent patents with those two words.

--------------------------------------------U.S. PATENTS-------------------------------------------------

Treatment of skin diseases using ginkgolide PAF antagonists

Inventor(s): Ruth Korth, D 80639 and assigned to Ruth Korth, Munich, Germany.

U.S. Patent 5,605,927, February 25, 1997.

Treatment and prevention of several skin disorders by topical or oral use of ginkgolides from Ginkgo biloba. Disorders include: sclerotic, genetic and thermic diseases. Phytochemistry described may interfere with the inflammatory process.

Anxiolytic ginger/ginkgo combination

Inventor(s): Rudiger Hacker, Claudia Mattern, assigned to Arrowdean Limited, Dublin, Ireland

U.S. Patent 5,622,704, April 22, 1997

Composition of Zingiber officinale and Ginkgo biloba for treating anxiety.

Terpenoid-type quinones for treatment of diabetes

Inventor(s): Rosa Pl Ubillas, Jolad D, Shivanand, Christopher D, Nebdez, Diana M. Fort, Joseph L. Evans, Jian Luo assigned to Shaman Pharmaceuticals, Inc. South San Francisco, CA. (Authors note: Shaman Pharmaceuticals, Inc. is not a viable business as of this writing patents 5,629, 319 and patent 5, 681,958 were also assigned to Shaman Pharmaceuticals as hypoglycemic agents. Respectively, the alkaloid extracts come from Cryptolepis sanguinolenta (Lindl.) Schltr, family Asclepiadaceae and analogs of cryptolepine.)

U.S. Patent 5,674,900, October 7, 1997.

To protect novel terpenoid-type quinones and process of obtaining them from the leaves and stems of Pycnanthus angolensis (Welw.) Warb., Family: Myristicaceae to be used as a hypoglycemic agent to treat diabetes in type 1 and type 2 individuals.

Extracts of Ginkgo biloba and their methods of preparation

Inventor(s): Ezio Bombardelli, Giuseppe Mustich and Marco Bertani, assigned to Indena, SpA, Milan, Italy

U.S. Patent 5,700,468, December 23, 1997

Protects process and production of a purified extract from Ginkgo biloba to include dimeric flavones.

Herbal compound for relief of PMS through menopausal symptoms.

Inventor(s): Tim Morrow, assigned to Sabina International, Ltd., Aspen CO.

U.S. Patent 5.707,630, January 13, 1998.

Protects a compound to relieve premenstrual symptoms made with red raspberry, bayberry, blue cohosh, capsicum, cascara sagrada, damiana, ginger, valerian in a ratio of two parts red raspberry to one part of the other herbal ingredients. The binding agent is described: cellulose and a food carrier of vegetable powder. The herbal is taken on an empty stomach for the treatment of PMS.

Anti-acne Composition Containing a Poria cocos Extract

Inventor(s): Alain Meybeck, Frederic Bonte, assigned to LVMH Recherche, France.

U.S. Patent: 5,716,800, February 10, 1998.

The fungus, Poria cocos treatment formula, extraction process and modes of application.

Use of Medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulation hair re growth or delaying hair loss.

Inventor(s): Frederic Bonte, Alain Meybeck, Georges Massiot, assigned to LVMH Recherche, Colombes, Cedex, France

U.S. Patent 5,723,149, March 3, 1998

Saponins and sapogenins from leaf or root extracts of Medicago genus (ex: alfalfa) in compositions for the preparation of cosmetics and pharmaceuticals to promote renewal of epidermis, stimulate hair re-growth, delay hair loss, combating the effects of ageing on skin and scalp.

Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba

Inventor(s): Lotfy Ismail Omar, Kew Gardens, NY.

U.S. Patent 5,730,987, March 24, 1998

Manufacture process and method of use freeze dried sturgeon roe and freeze dried powdered extract of Ginkgo biloba leaves.

Furanoeremophilane and eremophilanolide sesquiterpenes for treatment of diabetes.

Inventor(s): Wayne D. Inman, Steven Row King, Joseph L. Evans, Jian Luo assigned to Shaman Pharmaceuticals, Inc. South San Francisco, CA (out of business as of this writing).

U.S. Patent 5,747,527 May 5, 1998

Hypoglycemic chemistry isolated from Psacalium decompositum and related Psacalium species to include: eremophilanolide sesquiterpenes. Protects extraction process and use for epicacalone, cacalone, cacalol or dimaturin. Patent also describes administration of these compounds in conjunction with other hypoglycemic agents to treat both type 1 and type 2 diabetes.

Bioflavanoids and derivatives thereof as antiviral agents

Inventor(s): Yuh-Meei Lin, Michael T. flavin, Ralph Schure, David E. Zembower, Gen-Xian Zhao, assigned to MediChem Research, Inc. Lemont IL.

U.S. Patent 5,773,462, June 30, 1998

Covers antiviral effects of biflavanoids--derivatives and salt forms of robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a and GB-2a�from seeds of (Wax Tree) Rhus succedanea and Garcinia multiflora. Protects proprietary methods of preparing and use for treating and/or preventing viral infections caused by viral agents to include but not limited to influenza A and B, HIV, hepatitis, herpes viruses, varicella zoster virus and measles.

Compositions for curing diabetes mellitus, processes for the preparation of same, and usage of same.

Inventor(s): Masakiyo Takahashi, Fukuoka 814-01 Japan.

U.S. Patent 5,773,004, June 30, 1998

Protects the synergistic use of plant extracts in a two part formula.

First is a solvent extract in tea, drink or other formulation from Tithonia diversifolia (Hemsl.) (Common name: Tree Marigold) and Tithonia rotundifolia (Mill) (common name Mexican Sunflower) T. fruticosa Canby & rose, T. scaberrima Benth. and/or T. longeradiata (Bertol) Brake.

Part two of the formula covers extract of Ludwigia octovalvis (Raven) (common name: Primrose Willow), L. prostrata Roxb., or L. epilobioides Maxim. Consumption of the two part formula is reported to alleviate or diminish symptoms of diabetes mellitus: lowers blood glucose levels, prevents recurrence of diabetes mellitus for an extended period of time.

Cranberry extract and biologically active compounds derived there from.

Inventor(s): Edward B. Walker, Richard Mickelsen, Jennifer Michelsen, assigned to JLB, Inc, Ogden, Utah.

U.S. Patent 5,646,178, July 8, 1998

Methods of preparing and using antibacterial extracts form Vaccinium, family Ericaceae including cranberries. Protects extraction, purification and formulation of compounds including procyanidins, leucocyanin, leucodelphinin, flavonol glucosides. Also, describes composition with other polyphenols and flavonoid compounds all of which have reported anti-adhesion qualities. Covers formulation and preparation into tablets, capsules, liquids, gels, emulsions for topical application to body tissues and medical and dental instruments.

Herbal Appetite Suppressant and Weight Loss Composition

Inventor(s): Brian Haveson assigned to HPF, L.L.C., Horsham, PA.

U.S. Patent 5,798,101, August 25, 1998

St. John�s Wort (Hypericum perforatum) in composition with or without stimulants such as caffeine and Mahuang (Ephedra sinica). (Author�s note: This is composition that combine the effects of stimulants, suppressants, and antidepressants.

Nutritional supplement composition and use.

Inventor(s): Houn Simon Hsia, David Fan, assigned to Viva America Marketing Inc., Costa Mesa, CA.

U.S. Patent 5,976,548, November 2, 1998.

A composition of barley grass extract, multi vitamins and minerals with Ginkgo biloba extract that acts to increase blood levels of High Density Lipoproteins (HDL) and calcium ions, reduce free radicals and glucose levels in human plasma.

Lobeline Compounds as a Treatment for Psychostimulant Abuse and Withdrawal, and for Eating Disorders

Inventor(s): Peter A. Crooks, Linda P. Dwoskin, assigned to U. of Kentucky research Foundation, Lexington, KY.

U.S. Patent 5, 830,904, November 3, 1998.

The use of lobeline, lobelanidine, lobelanine and their pharmaceutically active salts for subcutaneous, intramuscular, intravenous, transdermal, oral, intranasal or rectal delivery for the treatment of drug dependence, drug withdrawal and eating disorders. To be used for the potential therapeutic treatment of drug abuse withdrawal from amphetamines, caffeine, cocaine, phencyclidine, opiates, barbiturates, benzodiazepines, hallucinogens, alcohol, cannabinoids and as an appetite suppressant.

Method of reducing blood glucose by administering Harunganin or Vismin

Inventor(s): Wayne DeWald Inman, Jian Luo assigned to Shaman Pharmaceuticals, Inc.

U.S. Patent 5,837,255, November 17, 1998.

Protects extracts of harunganin and vismin from Harungana and/or Vismia species as hypoglycemic agents for the treatment of both type 1 and type 2 diabetes. Covers extraction process and use adjuvant to established therapeutic hypoglycemic agents. Preferred formulation is from Harungana madagascariensis.

Nontoxic extract of Larrea tridentata and method of making same.

Inventor(s): Robert A. Sinnott, W. Dennis Clark, Kenneth Frank DeDoer, assigned to Larreacorp, Ltd. Chandler, AZ.

U.S. Patent 5,837,252, November 17, 1998.

Protects a non-toxic anti-inflammatory and antiviral agent from an extract of Larrea tridentata (common name: chapparal). Chapparal extract has long been considered toxic. This patent protects a process during processing of reducing nordihydroguaiaretic acid quinone, a toxic substance. The extract to be used to treat Herpesviridae family diseases.

Herbal Composition for Hemorrhoid Treatment

Inventor(s): Mercedes Flores, assigned to Mon�s Tea Partnership, Houston, TX.

U.S. Patent 5,869,059, February 9, 1999.

This anti-hemorrhoidal composition includes a herb from Equisetaceae (horsetail) and a herb from Julianiaceae called cuachalalate. The dried herbs are covered in three forms: tea bags, powder, capsules or tablets.

Natural Composition Extracted from Plants used in the Treatment of Cancer

Inventor(s): Howard David Kass, Arnold I Freeman, Albert Leyva, Applicant: Howard David Kass

U.S. Patent 5,876,728, March 1999

Describes preparation and administration of a cancer treatment composed of three plant extracts to include goldenseal (30% to 70 % by weight); myrtle (20% to 40% by weight) and Centaurea (5% to 20%). As part of the patent seven additional herbal extracts by composition were described: Centaurea (3 to 5 % by weight); lobelia (1.5 to 4% by weight); capsicum (1.5 to 4% by weight); myrrh (20 to 40% by weight); Echinacea (30 to 50% by weight); goldenseal (15 to 25% by weight); myrtle (3 to 5% by weight). The patent describes that the herbs are prepared by traditional solvent extraction using water and or alcohol. Dosage of the specified liquid extract composition is 10 to 40 drops, four to six times per day.

Preparations of Crataegus species pharmaceutical compositions and their use for preventing sudden death due to cardiac arrest and reperfusion-caused cardiovascular lesions

Inventor(s): Shyam Sunder Chatterjee, Herman Ernst Jaggy assigned to Willmar Schwabe GmbH & Company, Germany.

U.S. Patent 5,925,355, July 20, 1999.

Processed extracts of leaves with flowers of one or more of several Crataegus species provide cardioprotective effects in cases of cardiac ischemia and life-threatening reperfusion-induced cardiovascular lesions. Three new fractions are isolated and have showed potential in animal studies.

Natural preparation for treatment of male pattern hair loss.

Inventor(s): Stephen Chizick, Rico Delorscior, Toronto, CA., assigned to Proguard.

U.S. Patent 5, 972,345, October 26, 1999.

Protect the concept that by using a combination of herbs to reduce the elevated levels of 5-alpha-reductase associated with Benign Prostatic Hyperplasia (BPH) may also help control male pattern hair loss, which is also associated with elevated levels of 5-alpha-reductase in the scalp. Specified herb combinations include: Serenoa repens, Prunus africanum, Pygeum africanus, Urtica dioica with vitamins, minerals, phytochemicals in natural formulation

Compositions for treating and preventing diabetes, impaired glucose tolerance and related symptoms, and methods for preparing and using such compositions.

Inventor(s): Edayatimangalam Raja Bhavani Shanmugasundaram, Kalathinkal Radha Shanmugasundaram, Rolland Herbert, Sohail Malik, Michael Baker; assigned to Pharma Terra, Inc. Bellevue, WA

U.S. Patent 5,980,902, November 9, 1999.

Methods of isolating compositions from the leaves of Gymnema sylvestre (Retz.) Sm.. Asclepiadaceae (Ayurvedic medicine name: gurmar) for sub cutaneous, transdermal, intravenous oral administration to patients with diabetes both type 1 and type 2. This broad patent makes numerous claims including the regeneration of islets of Langerhans cells in the pancreas.

Composition for the treatment of viral infections including HIV

Inventor(s): Som C. Pruthi, Pankaj Pruthy, Jasvant Rai Pruthy, Boca Raton, FL.

U.S. Patent 5,980,903, November 9, 1999.

Patent addresses the composition of thymol from various plants and its use as an antiviral, including its ability inhibit viral replication of HIV. Thymol is available in numerous Labiatae plants to include basil, holy basil and thyme. Patent covers the formula for combining the ingredients from several plants containing thymol (including Bishop�s weed, Trachyspermum ammi (L.) Sprague and Umbelliferae) and laboratory results from using the drug with laboratory animals

Composition containing an extract from muira puama root and plant worm extract.

Inventor(s): Masaaki Hanawa, Hideaki Kitajima, Kemji Tsunoda assignd to Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.

U.S. Patent 6,024,984, February 15, 2000.

Protects a plant extract formula combining Ptychopetalum olacoides (muira puama) with a fungus from the Clavicipitaceae family to relieve physical and mental weakness. Plant composition may contain Ptychopetalum olacoides, Ptychopetalum uncinatum, Liriosma ovata, with the preferred species being Ptychopetalum olacoides. Fungus family members that may be used include: Simizuomyces, Torrbiella, Podonectrioides.

Method of preparation and composition of a water soluble extract of the plant species Uncaria

Inventor(s): Ronald W. Pero, assigned to CampaMed, Inc., NY, NY.

U.S. Patent 6,039,949, March 21, 2000.

Uncovers there is a high degree of biological activity in low-molecular weigh fraction of a whole plant hot water infusion of Uncaria tomentosa (cat�s claw). Protect traditional method of infusion with dialysis to yields a high amount of the immunostimulating, antiviral and anti-inflammatory activity. Inventor claims this fraction retains high bioactivity with less gastric irritation, less toxicity than other commercially similar products.

Turmeric for treating health ailments.

Inventor(s): Van Bich Nguyen, College Park, MD.

U.S. Patent 6,048,533, April 11, 2000.

Patent protects topical and oral administration of turmeric formulations with other ingredients as food supplements, capsules, ointments, salves, intravenous and suppository forms.


United States Patent



March 13, 2001


Methods and compositions for the treatment of sexual dysfunction in humans and animals.


Therapeutic composition for the treatment of sexual dysfunction and infertility in humans and animals and methods for the treatment of sexual dysfunction and infertility and the improvement of sexual desire in humans and animals by the administration of the composition. The composition comprises fish roe. The methods comprise the administration of fish roe and the administration of fish roe with yohimbine, estrogens, clomiphene, and Ginkgo biloba.


Omar; Lotfi Ismail (P.O. Box F396, Kew Gardens, NY 11415)

Appl. No.:



May 28, 1999

Current U.S. Class:

424/195.1; 561/451; 561/641; 561/682; 561/702; 514/78

Intern'l Class:

A61K 035/78

Field of Search:

424/195.1,561,451,641,682,702 514/78


United States Patent


Bonte , et al.

February 27, 2001

Use of Potentilla erecta extract in the cosmetic and pharmaceutical field.


The invention relates to the use of an extract of the plant Potentilla erecta in the field of cosmetics and pharmacy, especially in dermatology. The invention more particularly relates to any application in which it is sought to reinforce the dermo-epidermal junction or to improve hair condition, by the improvement of the synthesis of collagen VII by keratinocytes and/or fibroblasts. In particular, these applications concern toning of the skin, diminishing of wrinkles or hair care. The invention also relates to a novel method of culture of cells, in particular of human fibroblasts or keratinocytes, for promoting the formation of collagen VII.


Bonte; Frederic (Orleans, FR); Dumas; Marc (Orleans, FR); Chaudagne; Catherine (Vitry-Aux-Loges, FR); Meybeck; Alain (Courbevoie, FR)


LVMH Recherche (Paris, FR)

Appl. No.:


United States Patent



March 6, 2001


Prostate formula


A composition providing an all-natural, non-surgical preventative of or improvement to disorders of the prostate gland is described. The invention relates to a composition for the prevention of or improvement of prostatitis, and for relieving symptoms and improving objective signs of prostatitis. The formula of the composition preferably includes the following ingredients each in a therapeutically effective amount: Vitamin C, Vitamin B6, Vitamin E, zinc, glycine, L-alanine, Glutamic acid, Saw palmetto, Pygeum extract, Pumpkin seed, Stinging nettle, Echinacea, garlic, Ginkgo leaves, and selenium.


Wheeler; Ronald E. (412 C.R. 243, Durango, CO 81301)

Appl. No.:



August 3, 1999

Current U.S. Class:

424/195.1; 424/641

Intern'l Class:

A61K 035/78; A61K 033/32

Field of Search:



United States Patent


Quan , et al.

January 30, 2001

Antioxidant composition for topical/transdermal prevention and treatment of wrinkles


An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.   Bioflavonoids as antioxidants from Ginkgo are part of this composition.


Quan; Danyi (Salt Lake City, UT); Venkateshwaran; Srinivasan (Salt Lake City, UT); Ebert; Charles D. (Salt Lake City, UT)


Watson Pharmaceuticals, Inc. (Corona, CA)

Appl. No.:



November 24, 1998

Current U.S. Class:

424/448; 424/78.02; 424/195.1; 424/443; 424/444; 424/445; 424/447; 424/449; 514/23; 514/54; 514/62; 514/159; 514/263; 514/359; 514/408; 514/423; 514/424; 514/428; 514/458; 514/474; 514/553; 514/557; 514/561; 514/563; 514/579; 514/725; 514/772; 514/772.2; 514/772.3; 514/772.4; 514/777; 514/783; 514/844; 514/848; 514/975

Intern'l Class:

A61K 009/70; A61K 031/045; A61K 031/13; A61K 031/16; A61K 031/19; A61K 031/34; A61K 031/355; A61K 031/375; A61K 031/40; 772; 772.2; 772.3; 772.4; 777; 783; 844; 848; 975; 62

Field of Search:

514/458,474,725,159,183,359,408,423,424,428,553,557,561,563,579,263,54,42,23 424/195.1,449,443,447,448,444,445,78.02


United States Patent


Keller , et al.

January 30, 2001

Symptomatic relief of allergic reactions.


The composition disclosed is a unique formulation of Traditional Chinese Medicine (TCM) extracts created to reduce the debilitating symptoms of allergies. It combines a number of organically grown, but, non-organically extracted, standardized formulations of natural ingredients which have been used singly for hundreds of years for symptomatic relief of allergies. These include Ginseng and Gan Cao, which provide a natural anti-inflammatory effect; Bai Gao, which prevent the smooth muscle spasms associated with allergic reactions; Suan Zao ren, which provides an antihistamine effect without the usual sedative effect; and Wu Mai, which reduces the local swelling associated with allergies. Combined, it was unexpectedly found that these ingredients provide a natural, non-drying, non-sedating alternative to antihistamines, without inhibiting the natural healing mechanisms.   Ginkgo extract is mentioned in the body of the patent.


Keller; Robert H (Weston, FL); Wen; Xue-Lan (Miami, FL)


Vit-Immune, L.C. (Hollywood, FL)

Appl. No.:



July 8, 1999

Current U.S. Class:


Intern'l Class:

A01N 065/00; A61K 035/78

Field of Search:

424/195.1 514/783


United States Patent


Fisher , et al.

October 10, 200

Methods for inhibiting photoaging of skin


Methods are provided for ameliorating various effects of UVA and UVB radiation from the sun, comprising administering compositions including an ingredient that prevents photoaging from MED and subMED radiation, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C) and optionally other MMP inhibitors such as tetracyclines and/or compounds that inhibit the P-450-mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; depending upon the ingredients used in the composition, application should be from 7 to 48 hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.


More....Various compounds termed "antioxidants" are also useful as MMP inhibitors. While not desirous of being constrained to any particular theory of operation, these compounds may quench or otherwise reduce free radicals and reactive oxygen species which may initiate or lead to MMP induction, such as via the MAP kinase cascade. These compounds include glutathione and its precursors, such as N-acetyl cysteine (NAC) or glutathione ethyl ester, more broadly N-CH.sub.3 (CH.sub.2).sub.n CO cysteine (wherein n is an integer from zero to eight, more preferably not more than 4), and related compounds and derivates thereof as described in U.S. Pat. No. 5,296,500 (the disclosure of which is incorporated herein by reference). These other MMP inhibitors include water-soluble compounds such as vitamin C and NAC, and FDO. Various other compounds that may act as MMP inhibitors include: lipid-soluble compounds such as .beta.-carotene and its derivatives or other carotenoids; glutathione and derivatives thereof (or of NAC); .alpha.-lipoic acid (1,2-dithiolane-3-pentanoic acid); selenium compounds such as Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one); isoflavones such as genistein (isoflavone), quercetin (flavon-3-ol), and pycnogenol (flavan-3-ol(s)); ergothioneine; saponin (e.g., from Polypodium leucotomos); Ginkgo biloba extract (flavoneglycoside and terpenelactone) and feverfew (Chrysanthemum parthenium) extract (sesquiterpene lactone). Various UV blockers are known in the paint and dye industry to prevent pigment or color degradation of cars, homes, and clothing. A particularly preferred UVA.sub.1/2 -blocker for use on human skin is PARSOL.RTM. 1789 (Schering-Plough), as well as those in the aforementioned U.S. Pat. No. 4,387,089 that describes the preparation of this UVA-blocker. We have found that true UVA blockers inhibit induction of cJUN mRNA and of collagenase and gelatinase. The compositions of this invention can be provided in any cosmetically suitable form, preferably as a lotion or cream, but also in an ointment or oil base, as well as a sprayable liquid form (e.g., a "hair" spray that protects hair and scalp against UV damage, in a base that dries in a cosmetically acceptable way without the greasy appearance that a lotion or ointment would have if applied to the hair). In addition, the compositions contemplated by this invention can include one or more compatible cosmetically acceptable adjuvants commonly used, such as colorants, fragrances, emollients, humectants, and the like, as well as botanicals such as aloe, chamolile, and the like. When used topically, retinoids are used preferably at concentrations of between about 0.05% and about 5%, more preferably between 0.1% and 1%. Retinoids and the various antioxidants described above can also be taken systemically, preferably by oral administration. When dosed orally, retinoids are preferably administered in amounts from about 0.1 mg/kg (of body weight) to about 1 mg/kg or even more, all doses below that at which toxicity is likely; and antioxidants are preferably taken in "megadoses" (e.g., at least 1 g/d of vitamin C, at least 1000 I.U. of one or more tocopherols). In summary, our invention is broadly viewed as refocussing the concept of preventing "photoaging" from preventing sunburn to preventing the increase in MMP activity following UV exposure. Our invention provides prophylaxis against photoaging through one or more modes: blocking UVA/B radiation at the level of the skin by use of a UVA/B blocking sunscreen; blocking the generation by UV radiation of reactive oxygen species in the skin that initiate the MAP kinase cascade and MMP induction by the topical application of an antioxidant; blocking the induction of transcription factors leading to increased MMP activity after UV exposure by the topical application of a retinoid or an MMP inhibitor (as broadly defined herein); directly inhibiting MMP activity by the topical application of an inhibitor thereof; and/or by blocking the transmission of UVA radiation through a window structure to human skin by providing in the structure, or in a coating on the structure, a UVA blocker.

United States Patent


Ramazanov , et al.

September 12, 2000

Method for obtaining an extract from Ginkgo biloba leaves.


A novel and environmentally friendly method is disclosed for producing a purified extract from Ginkgo biloba leaves comprising the novel steps of differential centrifugation and extraction with supercritical CO.sub.2.

More....We claim: 1. A method of preparing a Ginkgo biloba extract comprising the steps of (i) extracting Ginkgo biloba leaves with an alcohol/water solution; (ii) removing particulate materials from said solution; (iii) removing alcohol from said solution to form an aqueous suspension; (iv) subjecting said aqueous suspension to differential centrifugation to form a second solution; (v) drying the second solution to form a solid; and (vi) extracting said solid with supercritical CO.sub.2 to yield said Ginkgo biloba extract, said extract product containing less than 5 ppm in total of ginkgolic acid and ginkgolic acid derivatives.


Ramazanov; Zakir (Warwick, NY); Bernal Suarez; Maria del Mar (Warwick, NY)


Pharmline Inc. (Florida, NY)

Appl. No.:



December 3, 1999

Current U.S. Class:


Intern'l Class:

A01N 065/00

Field of Search: